Imidazo[1,2-a]pyridine-2-ethanamine,dihydrochloride
2-imidazo[1,2-a]pyridin-2-ylethanamine dihydrochloride
CAS: 51132-02-6
Molecular Formula: C9H13Cl2N3
Imidazo[1,2-a]pyridine-2-ethanamine,dihydrochloride - Names and Identifiers
| Name | 2-imidazo[1,2-a]pyridin-2-ylethanamine dihydrochloride |
| Synonyms | Imidazo[1,2-a]pyridine-2-ethanamine,dihydrochloride 2-imidazo[1,2-a]pyridin-2-ylethanamine dihydrochloride 2-Imidazo[1,2-a]pyridin-2-yl-ethylamine dihydrochloride 2-(Imidazo[1,2-a]pyridin-2-yl)ethanamine dihydrochloride |
| CAS | 51132-02-6 |
| InChI | InChI=1/C9H11N3.2ClH/c10-5-4-8-7-12-6-2-1-3-9(12)11-8;;/h1-3,6-7H,4-5,10H2;2*1H |
Imidazo[1,2-a]pyridine-2-ethanamine,dihydrochloride - Physico-chemical Properties
| Molecular Formula | C9H13Cl2N3 |
| Molar Mass | 234.12562 |
Imidazo[1,2-a]pyridine-2-ethanamine,dihydrochloride - Introduction
2-imidazo[1,2-a]pyridin-2-ylethanamine dihydrochloride is an organic compound also known as 2-imidazo[1,2-a]pyridin-2-ylethanamine dihydrochloride.
Nature:
-Appearance: White crystalline powder or crystal.
-Solubility: Soluble in water, methanol and ethanol.
Use:
-Drug research: 2-imidazo[1,2-a]pyridin-2-ylethanamine dihydrochloride can be used to synthesize biologically active compounds, such as anti-tumor drugs, anti-inflammatory drugs, etc.
Preparation Method:
2-imidazo[1,2-a]pyridin-2-ylethanamine dihydrochloride can be synthesized by the following steps:
1. reacting 2-aminomethyl pyridine with sodium bisulfite to give 2-pyridone.
2. Knoevenagel condensation reaction of 2-pyridone and methyl ketene to generate 2-pyridone acetone.
3. reacting 2-pyridineneacetone with imidazolidine in acetic acid to generate imidazole [1,2-a] pyridine-2-ethylamine.
4. Finally, imidazole [1,2-a] pyridine-2-ethylamine was crystallized as hydrochloric acid to obtain pure product.
Safety Information:
2-imidazo[1,2-a] The safety of pyridin-2-ylethanamine dihydrochloride has not been fully studied, so relevant laboratory safety guidelines should be followed during operation and appropriate personal protective equipment should be used.
Nature:
-Appearance: White crystalline powder or crystal.
-Solubility: Soluble in water, methanol and ethanol.
Use:
-Drug research: 2-imidazo[1,2-a]pyridin-2-ylethanamine dihydrochloride can be used to synthesize biologically active compounds, such as anti-tumor drugs, anti-inflammatory drugs, etc.
Preparation Method:
2-imidazo[1,2-a]pyridin-2-ylethanamine dihydrochloride can be synthesized by the following steps:
1. reacting 2-aminomethyl pyridine with sodium bisulfite to give 2-pyridone.
2. Knoevenagel condensation reaction of 2-pyridone and methyl ketene to generate 2-pyridone acetone.
3. reacting 2-pyridineneacetone with imidazolidine in acetic acid to generate imidazole [1,2-a] pyridine-2-ethylamine.
4. Finally, imidazole [1,2-a] pyridine-2-ethylamine was crystallized as hydrochloric acid to obtain pure product.
Safety Information:
2-imidazo[1,2-a] The safety of pyridin-2-ylethanamine dihydrochloride has not been fully studied, so relevant laboratory safety guidelines should be followed during operation and appropriate personal protective equipment should be used.
Last Update：2024-04-09 21:00:56
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